Volume Articles

Commentary: New design of nucleotide excision repair (NER) inhibitors for combination cancer therapy

Francesco Gentile¹, Jack A. Tuszynski^1,2 and Khaled H. Barakat³*

Commentary: Eight Year Survival Analysis of Patients with Triple Negative Breast Cancer in India

Dinesh Chandra Doval^1*, Atika Dogra^{2 3}

Commentary: A systemic digestive allergic reaction imputable to docetaxel in a breast cancer patient

Diaddin Hamdan^1,2, Anne Janin^2,3*, Guilhem Bousquet^{2, 4, 5#}

Understanding colorectal cancer in Malaysia: A mini-review and pioneering colorectal cancer awareness, screening and treatment project

Christina Ng Van Tze^1*, Henry Fitzgerald², Akhtar Qureshi³, Huck Joo Tan³, May Lee Low⁴, Mun Kit Lim⁴, Vui Chee Lo¹

Colorectal cancer is a major cause of morbidity and mortality worldwide. It has been identified as the most common cancer in men and second most common cancer in women in Malaysia. This mini-review is meant to present the current state and overview of colorectal cancer in Malaysia. Our efforts through EMPOWERED, The Cancer Advocacy Society of Malaysia to reduce the toll of colorectal cancer through a customised annual Colorectal Cancer Awareness, Screening and Treatment Project with high compliances are also briefly summarised.

Further remarks on potential implementation of the ESC and iPSC technology in clinical practice

Jaroslaw Lewandowski and Maciej K Kurpisz*

The first clinical trials subdued optimistic forecasts of the rapid use of iPSC technology across a large spectrum of diseases. However, positive safety results originating from administration of differentiated ESCs to first patients can be treated as the promise to future of this regenerative medicine branch. Advances in non-viral methods for pluripotency induction, including episomal and mRNA strategies as well as microRNA switches robustly purifying heterogeneous differentiated PSCs may accelerate further progress. In the present decade the development of an effective genome editing including CRISPR/Cas9, novel therapeutic approach and intensive research in 3D in vitro culture systems including tissue engineering can further expand the potential of iPSCs. The herein mini-review article extends and updates the current approaches in state-of-the-art techniques of human embryonic stem cell and induced pluripotent stem cell derivation.

Chlorine dioxide as a possible adjunct to metabolic treatment

Laurent Schwartz

Assistance Publique des Hôpitaux de Paris, Avenue Victoria 75003 Paris, France

A first patient with metastatic adenocarcinoma of the pancreas has decided, on his own, to refuse chemotherapy but to treat himself with lipoïc acid, hydroxycitrate combined with oral ingestion of chlorine dioxide. His blood tests and radiological examinations have almost normalized and the disease is stable at 18 months. Another patient with hormone resistant metastatic prostate cancer has experienced a sharp drop in PSA level as well as improved medical condition. From extensive literature review, the mechanism of action of chlorine dioxide is unknown. It is our hypothesis (albeit unproven) that chlorine dioxide results in tumor cell acidification of the alkaline pH of cancer cells.